Issue 2, 2013

Preparation and evaluation of BBB-permeable trehalose derivatives as potential therapeutic agents for Huntington's disease

Abstract

The BBB-permeable trehalose derivative (TD-G6) was found to efficiently prevent the aggregation of polyQ in the transfected HEK293 cells. Furthermore, it was also found to significantly prolong lifespan, improve motor functions, and reduce the inclusion bodies in a transgenic mouse model (Tg R6/2), when given ad libitum.

Graphical abstract: Preparation and evaluation of BBB-permeable trehalose derivatives as potential therapeutic agents for Huntington's disease

Supplementary files

Article information

Article type
Concise Article
Submitted
02 May 2012
Accepted
19 Oct 2012
First published
22 Oct 2012

Med. Chem. Commun., 2013,4, 310-316

Preparation and evaluation of BBB-permeable trehalose derivatives as potential therapeutic agents for Huntington's disease

J. Im, S. Kim, Y. Jeong, W. Kim, D. Lee, W. S. Lee, Y. Chang, K. Kim and S. Chung, Med. Chem. Commun., 2013, 4, 310 DOI: 10.1039/C2MD20112G

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