Issue 7, 2012

Catalytic intermolecular hydroacylation of C–C π-bonds in the absence of chelation assistance

Abstract

Intermolecular rhodium catalyzed hydroacylation in the absence of chelation assistance remains a largely unmet challenge due to competing decarbonylation of the acylrhodium intermediates to form catalytically inactive carbonyl complexes. Here, catalytic systems for intermolecular hydroacylation in the absence of chelation assistance are reviewed, with an emphasis on recently described processes that operate through mechanistic pathways beyond aldehyde C–H oxidative addition.

Graphical abstract: Catalytic intermolecular hydroacylation of C–C π-bonds in the absence of chelation assistance

Article information

Article type
Minireview
Submitted
19 Mar 2012
Accepted
11 Apr 2012
First published
02 May 2012

Chem. Sci., 2012,3, 2202-2209

Catalytic intermolecular hydroacylation of C–C π-bonds in the absence of chelation assistance

J. C. Leung and M. J. Krische, Chem. Sci., 2012, 3, 2202 DOI: 10.1039/C2SC20350B

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