Issue 11, 2012

A copper-catalyzed arylation of tryptamines for the direct synthesis of aryl pyrroloindolines

Abstract

An operationally simple, copper-catalyzed arylation of N-tosyltryptamines provides direct access to C3-aryl pyrroloindolines. A range of electron-donating and electron-withdrawing substituents is tolerated on both the indole backbone and the aryl electrophile. These reactions occur under ambient temperatures and with equimolar quantities of the coupling partners.

Graphical abstract: A copper-catalyzed arylation of tryptamines for the direct synthesis of aryl pyrroloindolines

Supplementary files

Article information

Article type
Edge Article
Submitted
09 Jul 2012
Accepted
09 Aug 2012
First published
17 Aug 2012

Chem. Sci., 2012,3, 3170-3174

A copper-catalyzed arylation of tryptamines for the direct synthesis of aryl pyrroloindolines

M. E. Kieffer, K. V. Chuang and S. E. Reisman, Chem. Sci., 2012, 3, 3170 DOI: 10.1039/C2SC20914D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements