Issue 5, 2012
From the journal:

Soft Matter

Repetitive on-demand drug release by magnetic heating of iron oxide containing polymeric implants

Stefan A. Rovers,a   Richard Hoogenboom,*bc   Maartje F. Kemmere†a  and  Jos T. F. Keurentjes*a  

* Corresponding authors

a Process Development Group, Department of Chemical Engineering and Chemistry, Eindhoven University of Technology, P.O. Box 513, Eindhoven, The Netherlands
E-mail: j.t.f.keurentjes@tue.nl

b Dolphys Medical, Den Dolech 2, Eindhoven, The Netherlands
E-mail: richard.hoogenboom@ugent.be

c Supramolecular Chemistry Group, Department of Organic Chemistry, Krijgslaan 281-S4, Ghent, Belgium

Abstract

Drug release from a polymeric matrix has been externally triggered using an alternating magnetic field in order to develop an on-demand drug delivery implant. Superparamagnetic iron oxide nanoparticles have been distributed in a poly(methyl methacrylate) core, coated with a thermoresponsive layer of poly(butyl methacrylate-stat-methyl methacrylate) containing ibuprofen as a model drug. The release rate of ibuprofen reversibly increased, up to 25-fold, upon exposure to the magnetic field and was found to increase with higher iron oxide loading. Finally, magnetically triggered on-demand drug release was demonstrated under physiologically relevant conditions, namely 37 °C in PBS buffer with high ibuprofen content in the implant and only 15 minutes triggering time.

Graphical abstract: Repetitive on-demand drug release by magnetic heating of iron oxide containing polymeric implants

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Article information

DOI
https://doi.org/10.1039/C2SM06557F
Article type
Paper
Submitted
15 Aug 2011
Accepted
24 Nov 2011
First published
15 Dec 2011

Soft Matter, 2012,8, 1623-1627

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Repetitive on-demand drug release by magnetic heating of iron oxide containing polymeric implants

S. A. Rovers, R. Hoogenboom, M. F. Kemmere and J. T. F. Keurentjes, Soft Matter, 2012, 8, 1623 DOI: 10.1039/C2SM06557F

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