Issue 6, 2013

Synthesis and antiproliferative activity of some 3-(pyrid-2-yl)-pyrazolines

Abstract

The synthesis and antiproliferative activity of eleven 3-(pyrid-2-yl)-pyrazolines in two cancer cell lines are reported. X-ray crystallography was obtained of the lead compound 8i which was screened in the NCI 60 human tumour cell line and displayed sub-micromolar activity. Cell cycle analysis, in vitro tubulin assay and confocal microscopy are also reported and suggest that the lead compound disrupts microtubule formation.

Graphical abstract: Synthesis and antiproliferative activity of some 3-(pyrid-2-yl)-pyrazolines

Supplementary files

Article information

Article type
Concise Article
Submitted
06 Mar 2013
Accepted
23 Apr 2013
First published
24 Apr 2013
This article is Open Access
Creative Commons BY license

Med. Chem. Commun., 2013,4, 956-961

Synthesis and antiproliferative activity of some 3-(pyrid-2-yl)-pyrazolines

A. Ciupa, P. A. De Bank, M. F. Mahon, P. J. Wood and L. Caggiano, Med. Chem. Commun., 2013, 4, 956 DOI: 10.1039/C3MD00077J

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