Issue 11, 2013

Design, synthesis and antiproliferative activity of indole analogues of indanocine

Abstract

The design and synthesis of a novel series of indole-analogues of indanocine is reported, together with their antiproliferative activity in the NCI's panel of cancer cell lines. Indanocine displays potent activity against a wide range of cancer cell lines (mean GI50 < 20 nM), including drug-resistant cancer cell lines, and also inhibits the migration of metastatic cancer cells. A number of the described indole-analogues display a similar activity profile to indanocine, exhibiting potent antiproliferative activities in several cancer cell lines, and offer new leads for further development.

Graphical abstract: Design, synthesis and antiproliferative activity of indole analogues of indanocine

Supplementary files

Article information

Article type
Concise Article
Submitted
16 Jul 2013
Accepted
16 Sep 2013
First published
17 Sep 2013
This article is Open Access
Creative Commons BY license

Med. Chem. Commun., 2013,4, 1452-1456

Design, synthesis and antiproliferative activity of indole analogues of indanocine

G. A. Tunbridge, J. Oram and L. Caggiano, Med. Chem. Commun., 2013, 4, 1452 DOI: 10.1039/C3MD00200D

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