Issue 14, 2013
From the journal:

Organic & Biomolecular Chemistry

Broadening the catalyst and reaction scope of regio- and chemoselective C–H oxygenation: a convenient and scalable approach to 2-acylphenols by intriguing Rh(ii) and Ru(ii) catalysis†

Gang Shan,‡a   Xuesong Han,‡ab   Yun Lin,a   Shanyou Yua  and  Yu Rao*a  

* Corresponding authors

a Department of Pharmacology and Pharmaceutical Sciences, School of Medicine and School of Life Sciences, Tsinghua University, Beijing, China
E-mail: yrao@mail.tsinghua.edu.cn
Fax: (+86)10-62783404

b Shenyang Pharmaceutical University, Shenyang, China

Abstract

A unique Rh(II) and Ru(II) catalyzed C–H oxygenation of aryl ketones and other arenes has been developed for the facile synthesis of diverse functionalized phenols. The reaction demonstrates excellent reactivity, regio- and chemoselectivity, good functional group compatibility and high yields. The practicality of this method has been proved by gram-scale synthesis of a few different 2-acylphenols. Its utility has been well exemplified in further applications in heterocycle synthesis and direct modifications of drug Fenofibrate.

Graphical abstract: Broadening the catalyst and reaction scope of regio- and chemoselective C–H oxygenation: a convenient and scalable approach to 2-acylphenols by intriguing Rh(ii) and Ru(ii) catalysis

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Article information

DOI
https://doi.org/10.1039/C3OB27457H
Article type
Paper
Submitted
19 Dec 2012
Accepted
07 Feb 2013
First published
11 Feb 2013

Org. Biomol. Chem., 2013,11, 2318-2322

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Broadening the catalyst and reaction scope of regio- and chemoselective C–H oxygenation: a convenient and scalable approach to 2-acylphenols by intriguing Rh(II) and Ru(II) catalysis

G. Shan, X. Han, Y. Lin, S. Yu and Y. Rao, Org. Biomol. Chem., 2013, 11, 2318 DOI: 10.1039/C3OB27457H

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