Issue 7, 2014
From the journal:

Organic & Biomolecular Chemistry

KI-catalyzed arylation of benzothiazoles from the coupling of aryl aldehydes with benzothiazoles in neat water†

Yuyu Gao,a   Qiuling Song,a   Guolin Chenga  and  Xiuling Cui*a  

* Corresponding authors

a Engineering Research Center of Molecular Medicine, Ministry of Education, Key Laboratory of Xiamen Marine and Gene Drugs, Institutes of Molecular Medicine and School of Biomedical Sciences, Huaqiao University, Xiamen, China
E-mail: cuixl@hqu.edu.cn

Abstract

A KI-catalyzed oxidative coupling of benzothiazoles with aryl aldehydes has been developed using TBHP as an oxidant in neat water under metal free conditions. Various 2-aryl benzothiazoles were prepared in 36–79% yields for 28 examples. The mechanistic studies suggested that this transformation proceeded via a radical process.

Graphical abstract: KI-catalyzed arylation of benzothiazoles from the coupling of aryl aldehydes with benzothiazoles in neat water

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Article information

DOI
https://doi.org/10.1039/C3OB42318B
Article type
Communication
Submitted
20 Nov 2013
Accepted
02 Jan 2014
First published
06 Jan 2014

Org. Biomol. Chem., 2014,12, 1044-1047

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KI-catalyzed arylation of benzothiazoles from the coupling of aryl aldehydes with benzothiazoles in neat water

Y. Gao, Q. Song, G. Cheng and X. Cui, Org. Biomol. Chem., 2014, 12, 1044 DOI: 10.1039/C3OB42318B

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