Issue 1, 2014

Palladium-catalyzed base-accelerated direct C–H bond alkenylation of phenols to synthesize coumarin derivatives

Abstract

A palladium-catalyzed base-accelerated ortho-selective C–H alkenylation of phenols to synthesize bioactive coumarin derivatives was developed. The reaction condition was mild and the substrate scope was broad with both electron-neutral and electron-deficient phenols, which is complementary to the previous methods to synthesize electron-rich coumarins. Several bioactive molecules were functionalized and several coumarins with bioactive properties were synthesized. Mechanistic studies showed that this reaction underwent C–H bond activation via direct metallation rather than the Friedel–Crafts pathway.

Graphical abstract: Palladium-catalyzed base-accelerated direct C–H bond alkenylation of phenols to synthesize coumarin derivatives

Supplementary files

Article information

Article type
Research Article
Submitted
15 Oct 2013
Accepted
21 Nov 2013
First published
20 Dec 2013

Org. Chem. Front., 2014,1, 44-49

Palladium-catalyzed base-accelerated direct C–H bond alkenylation of phenols to synthesize coumarin derivatives

X. Zhang, Z. Li and Z. Shi, Org. Chem. Front., 2014, 1, 44 DOI: 10.1039/C3QO00010A

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