Issue 6, 2013

Chiral organic contact ion pairs in metal-free catalytic enantioselective oxidative cross-dehydrogenative coupling of tertiary amines to ketones

Abstract

A novel chiral organic contact ion-pair catalytic system has been developed for the transition-metal-free catalytic enantioselective oxidative cross-dehydrogenative coupling of tertiary amines to ketones for sp3 C–H functionalization. This new strategy provides an efficient and environmentally friendly way to access diversify optically active C1-alkylated tetrahydroisoquinoline derivatives from simple starting materials under mild conditions.

Graphical abstract: Chiral organic contact ion pairs in metal-free catalytic enantioselective oxidative cross-dehydrogenative coupling of tertiary amines to ketones

Supplementary files

Article information

Article type
Edge Article
Submitted
04 Mar 2013
Accepted
19 Mar 2013
First published
20 Mar 2013

Chem. Sci., 2013,4, 2645-2651

Chiral organic contact ion pairs in metal-free catalytic enantioselective oxidative cross-dehydrogenative coupling of tertiary amines to ketones

G. Zhang, Y. Ma, S. Wang, W. Kong and R. Wang, Chem. Sci., 2013, 4, 2645 DOI: 10.1039/C3SC50604E

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