Issue 9, 2013

Copper-mediated trifluoromethylation of propiolic acids: facile synthesis of α-trifluoromethyl ketones

Abstract

Copper-mediated decarboxylative trifluoromethylation provides a new protocol for the efficient preparation of α-trifluoromethyl ketones from propiolic acids. It was found that water is involved as a reactant in the reaction, which is significantly different from the previously reported decarboxylative fluoroalkylation reactions.

Graphical abstract: Copper-mediated trifluoromethylation of propiolic acids: facile synthesis of α-trifluoromethyl ketones

Supplementary files

Article information

Article type
Edge Article
Submitted
09 Jun 2013
Accepted
17 Jun 2013
First published
17 Jun 2013

Chem. Sci., 2013,4, 3478-3483

Copper-mediated trifluoromethylation of propiolic acids: facile synthesis of α-trifluoromethyl ketones

Z. He, R. Zhang, M. Hu, L. Li, C. Ni and J. Hu, Chem. Sci., 2013, 4, 3478 DOI: 10.1039/C3SC51613J

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