Issue 56, 2014
From the journal:

Chemical Communications

Separation and enrichment of enantiopure from racemic compounds using magnetic levitation†

Xiaochuan Yang,a   Shin Yee Wong,a   David K. Bwambok,b   Manza B. J. Atkinson,b   Xi Zhang,a   George M. Whitesides*b  and  Allan S. Myerson*a  

* Corresponding authors

a Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
E-mail: myerson@mit.edu

b Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA
E-mail: gwhitesides@gmwgroup.harvard.edu

Abstract

Crystallization of a solution with high enantiomeric excess can generate a mixture of crystals of the desired enantiomer and the racemic compound. Using a mixture of S-/RS-ibuprofen crystals as a model, we demonstrated that magnetic levitation (MagLev) is a useful technique for analysis, separation and enantioenrichment of chiral/racemic products.

Graphical abstract: Separation and enrichment of enantiopure from racemic compounds using magnetic levitation

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Article information

DOI
https://doi.org/10.1039/C4CC02604G
Article type
Communication
Submitted
08 Apr 2014
Accepted
21 May 2014
First published
21 May 2014

Chem. Commun., 2014,50, 7548-7551

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Separation and enrichment of enantiopure from racemic compounds using magnetic levitation

X. Yang, S. Y. Wong, D. K. Bwambok, M. B. J. Atkinson, X. Zhang, G. M. Whitesides and A. S. Myerson, Chem. Commun., 2014, 50, 7548 DOI: 10.1039/C4CC02604G

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