Issue 77, 2014

COSAN as a molecular imaging platform: synthesis and “in vivo” imaging

Abstract

A labelling method for the covalent attachment of radioiodine to the boron-rich 8-I-cobaltabisdicarbollide (I-COSAN) and a bi-functional (iodine and PEG) COSAN derivative, [3,3′-Co(8-I-1,2-C2B9H10)(8′-(OCH2CH2)2COOC6H5-1′,2′-C2B9H10)], is reported. Biodistribution studies in rodents using dissection/gamma counting and in vivo nuclear imaging have been performed. The general strategy reported here can be applied in the future to COSAN derivatives bearing a wide range of functionalities.

Graphical abstract: COSAN as a molecular imaging platform: synthesis and “in vivo” imaging

Supplementary files

Article information

Article type
Communication
Submitted
02 Jul 2014
Accepted
31 Jul 2014
First published
31 Jul 2014

Chem. Commun., 2014,50, 11415-11417

Author version available

COSAN as a molecular imaging platform: synthesis and “in vivo” imaging

K. B. Gona, A. Zaulet, V. Gómez-Vallejo, F. Teixidor, J. Llop and C. Viñas, Chem. Commun., 2014, 50, 11415 DOI: 10.1039/C4CC05058D

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