Issue 31, 2014

Organocatalytic synthesis of optically active β-branched α-amino esters via asymmetric biomimetic transamination

Abstract

This paper describes an efficient asymmetric biomimetic transamination of α-keto esters with a quinine-derived chiral base as the catalyst, giving a variety of β-branched α-amino esters in 50–96% yield and 87–95% ee.

Graphical abstract: Organocatalytic synthesis of optically active β-branched α-amino esters via asymmetric biomimetic transamination

Supplementary files

Article information

Article type
Paper
Submitted
01 Apr 2014
Accepted
19 May 2014
First published
20 May 2014

Org. Biomol. Chem., 2014,12, 5856-5860

Organocatalytic synthesis of optically active β-branched α-amino esters via asymmetric biomimetic transamination

C. Su, Y. Xie, H. Pan, M. Liu, H. Tian and Y. Shi, Org. Biomol. Chem., 2014, 12, 5856 DOI: 10.1039/C4OB00684D

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