Development of customized 3D printed stainless steel reactors with inline oxygen sensors for aerobic oxidation of Grignard reagents in continuous flow

Manuel C. Maier; René Lebl; Philipp Sulzer; Josef Lechner; Torsten Mayr; Matej Zadravec; Eyke Slama; Stefan Pfanner; Christoph Schmölzer; Peter Pöchlauer; C. Oliver Kappe; Heidrun Gruber-Woelfler

doi:10.1039/C8RE00278A

Development of customized 3D printed stainless steel reactors with inline oxygen sensors for aerobic oxidation of Grignard reagents in continuous flow†

Manuel C. Maier,

^ab René Lebl,^ac Philipp Sulzer,^ad Josef Lechner,^ab Torsten Mayr,

^ad Matej Zadravec,^a Eyke Slama,^a Stefan Pfanner,^e Christoph Schmölzer,^f Peter Pöchlauer,^f C. Oliver Kappe

^ac and Heidrun Gruber-Woelfler

*^ab

Author affiliations

* Corresponding authors

^a Center for Continuous Flow Synthesis and Processing (CC FLOW), Research Center Pharmaceutical Engineering GmbH (RCPE), Graz, Austria

^b Institute of Process and Particle Engineering, Graz University of Technology, Graz, Austria
E-mail: woelfler@tugraz.at

^c Institute of Chemistry, University of Graz, Graz, Austria

^d Institute of Analytical Chemistry and Food Chemistry, Graz University of Technology, Graz, Austria

^e Anton Paar GmbH, Graz, Austria

^f Patheon Austria GmbH & Co KG, part of Thermo Fisher Scientific, Linz, Austria

Abstract

Additive manufacturing has gained a lot of interest in recent years to create customized reactors and equipment for milli- and micro flow applications. This work presents the development of 3D printed stainless steel reactors for the oxidation of Grignard reagents in flow. In our first approach a 3D printed micro CSTR-cascade was designed as a tool to get more insight in the reaction kinetics. Novel optical sensors were integrated inline in the cascade to monitor the oxygen consumption in real time. Based on the obtained experimental data and CFD simulations, a customized 3D printed split and recombine reactor was designed especially for the needs of the reaction.

This article is part of the themed collection: Reaction Chemistry & Engineering Emerging Investigators

Reaction Chemistry & Engineering

Development of customized 3D printed stainless steel reactors with inline oxygen sensors for aerobic oxidation of Grignard reagents in continuous flow†

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Development of customized 3D printed stainless steel reactors with inline oxygen sensors for aerobic oxidation of Grignard reagents in continuous flow

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