Issue 21, 2019

Glucose regulation by modified boronic acid-sulfobetaine zwitterionic nanogels – a non-hormonal strategy for the potential treatment of hyperglycemia

Abstract

We have introduced a non-hormonal hyperglycemia treatment strategy by using an injectable glucose-responsive boronic acid- zwitterionic nanogel. The synthesized system, similar to an artificial liver, is capable of storing/releasing glucose at high/low blood glucose concentrations. In vivo performance revealed that the injection of the nanogels can effectively regulate blood glucose in type 1 diabetic rats for at least 6 hours.

Graphical abstract: Glucose regulation by modified boronic acid-sulfobetaine zwitterionic nanogels – a non-hormonal strategy for the potential treatment of hyperglycemia

Supplementary files

Article information

Article type
Communication
Submitted
24 Feb 2019
Accepted
14 May 2019
First published
15 May 2019

Nanoscale, 2019,11, 10167-10171

Glucose regulation by modified boronic acid-sulfobetaine zwitterionic nanogels – a non-hormonal strategy for the potential treatment of hyperglycemia

A. GhavamiNejad, B. Lu, A. Giacca and X. Y. Wu, Nanoscale, 2019, 11, 10167 DOI: 10.1039/C9NR01687B

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