Issue 11, 1997

Novel biocatalytic reduction of aryl azides: chemoenzymatic synthesis of pyrrolo[2,1-c][1,4]benzodiazepine antibiotics1

Abstract

The chemoselective reduction of aryl azides to aryl amines, and the synthesis of the imine-containing pyrrolo[2,1-c]- [1,4]benzodiazepine DNA-binding antitumour antibiotics by selective biocatalytic reductive cyclization of azido aldehydes, has been achieved by employing baker’s yeast.

Article information

Article type
Paper

Chem. Commun., 1997, 1015-1016

Novel biocatalytic reduction of aryl azides: chemoenzymatic synthesis of pyrrolo[2,1-c][1,4]benzodiazepine antibiotics1

A. Kamal, Y. Damayanthi, B. S. Narayan Reddy, B. Lakminarayana and B. S. Praveen Reddy, Chem. Commun., 1997, 1015 DOI: 10.1039/A701249G

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