Issue 20, 1997

N-Thiocarbonyl azasugars: a new family of carbohydrate mimics with controlled anomeric configuration

Abstract

Bicyclic azasugar glycomimetics structurally related to the polyhydroxy-indolizine and -piperidine series incorporating a stereoelectronically controlled pseudoanomeric axial hydroxy group have been prepared by tautomeric rearrangement of cyclic thiocarbamate precursors; preliminary enzyme inhibition tests show an increased selectivity towards yeast α-glucosidase for the α-D-glucopyranose analogue as compared with castanospermine or nojirimicin.

Article information

Article type
Paper

Chem. Commun., 1997, 1969-1970

N-Thiocarbonyl azasugars: a new family of carbohydrate mimics with controlled anomeric configuration

J. L. Jiménez Blanco, V. M. Díaz Pérez, C. Ortiz Mellet, J. Fuentes, J. M. García Fernández, J. C. Díaz Arribas and F. J. Cañada, Chem. Commun., 1997, 1969 DOI: 10.1039/A705755E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements