Issue 2, 1998

Synthetic study of marine lobane diterpenes: efficient synthesis of (+)-fuscol

Abstract

As part of a synthetic study on marine natural products, the enantioselective synthesis of (+)-fuscol 4, a representative lobane diterpene, has been achieved in 10 steps and ca. 20% overall yield from (4R,5R)-1-acetoxy-4-isopropenyl-5-methyl-5-vinylcyclohex-1-ene 3b, which itself has been prepared as a building block directed toward the asymmetric synthesis of natural products, in more than 40% overall yield from (+)-nopinone 1.

Article information

Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1998, 217-222

Synthetic study of marine lobane diterpenes: efficient synthesis of (+)-fuscol

H. Kosugi, O. Yamabe and M. Kato, J. Chem. Soc., Perkin Trans. 1, 1998, 217 DOI: 10.1039/A706162E

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