A new convenient route for direct trifluoromethylation of steroidal compounds is described. Steroidal alkenyl bromides, derived from steroidal unsaturated ketones, react with FO2SCF2CO2Me in the presence of CuI in DMF to give the corresponding trifluoromethylated steroids in good yields (70–91%).
X. Fei, W. Tian and Q. Chen, J. Chem. Soc., Perkin Trans. 1, 1998, 1139 DOI: 10.1039/A706552C
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