Issue 4, 1998

LNA (locked nucleic acids): synthesis and high-affinity nucleic acid recognition

Abstract

A novel class of nucleic acid analogues, termed LNA (locked nucleic acids), is introduced. Following the Watson–Crick base pairing rules, LNA forms duplexes with complementary DNA and RNA with remarkably increased thermal stabilities and generally improved selectivities.

Article information

Article type
Paper

Chem. Commun., 1998, 455-456

LNA (locked nucleic acids): synthesis and high-affinity nucleic acid recognition

S. K. Singh, A. A. Koshkin, J. Wengel and P. Nielsen, Chem. Commun., 1998, 455 DOI: 10.1039/A708608C

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