Universality of LNA-mediated high-affinity nucleic acid recognition

Abstract

LNA (locked nucleic acid) is a novel class of nucleic acid mimic structurally closely resembling RNA; incorporation of three LNA monomers together with six ribonucleotide monomers afforded the first ribo-LNA sequence; unprecedented thermal stabilities of duplexes towards complementary DNA and RNA without compromising base-pairing selectivity were obtained for ribo-LNA, thus establishing the universality of LNA-mediated efficient targeting of natural nucleic acids.