The first electrochemical study of epidithiopiperazine-2,5-diones, a special class of α,α′-disulfide bridged cyclic dipeptides

Abstract

Polarographic stufies of 3,6-epidithiopiperazine-2,5-diones (ETP) including naturally occurring gliotoxin and simple synyhetic analogues are pertinent to understanding their biological action; coulometric measurements on 1,4-diethyl ETP in acetonitrille establish the existance of a ready one-electron reduction overall, in sharp contrast to the familiar two-electron cleavage of acyclic disulfides.