A study of the electrochemical oxidation of some 1,4-benzodiazepines

Abstract

The electrochemical oxidation of the 1,4-benzodiazepines flurazepam, chlordiazepoxide, oxazepam, lorazepam, potassium chlorazepate, nitrazepam, flunitrazepam, prazepam, diazepam and medazepam and some of their metabolites has been investigated at a glassy carbon electrode in Britton-Robinson buffers (pH 2–10) and in 0.01 M sodium hydroxide solution, each containing 10% of methanol. Oxidation mechanisms are proposed and analytical applications for use in assays of formulations and biological fluids are recommended.