Issue 7, 2001
From the journal:

Journal of the Chemical Society, Perkin Transactions 1

Enantioselective synthesis of hydroxy ketones through cleavage and formation of acyloin linkage. Enzymatic kinetic resolution via C–C bond cleavage

Ayhan S. Demir,ab   Martina Pohl,c   Elena Janzenc  and  Michael Müller*a  

* Corresponding authors

a Institut für Biotechnologie 2, Forschungszentrum Jülich GmbH, Jülich, Germany
E-mail: mi.mueller@fz-juelich.de

b Department of Chemistry, Middle East Technical University, Ankara, Turkey

c Institut für Enzymtechnologie der Heinrich-Heine, Universität Düsseldorf im Forschungszentrum Jülich, Jülich, Germany

Abstract

Both enantiomers of benzoins and (R)-2-hydroxy-1-phenylpropanone analogues were obtained in high yield on a preparative scale starting from aromatic aldehydes, rac-benzoins and aliphatic aldehydes via enzyme-catalysed C–C bond cleavage and C–C bond formation reactions.

Graphical abstract: Enantioselective synthesis of hydroxy ketones through cleavage and formation of acyloin linkage. Enzymatic kinetic resolution via C–C bond cleavage

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Article information

DOI
https://doi.org/10.1039/B100341K
Article type
Communication
Submitted
08 Jan 2001
Accepted
23 Feb 2001
First published
19 Mar 2001

J. Chem. Soc., Perkin Trans. 1, 2001, 633-635

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Enantioselective synthesis of hydroxy ketones through cleavage and formation of acyloin linkage. Enzymatic kinetic resolution via C–C bond cleavage

A. S. Demir, M. Pohl, E. Janzen and M. Müller, J. Chem. Soc., Perkin Trans. 1, 2001, 633 DOI: 10.1039/B100341K

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