Issue 15, 2001
From the journal:

Chemical Communications

Antibody-catalyzed activation of a model tripartate prodrug by a tandem hydrolysis–1,6-elimination reactionElectronic supplementary information (ESI) available: the synthesis and characterization of 3, and 9–11, and experimental details for kinetic studies and Lineweaver–Burk plots. See http://www.rsc.org/suppdata/cc/b1/b103971g/

A. Nicole Dinauta  and  Scott D. Taylor*a  

* Corresponding authors

a Department of Chemistry, University of Waterloo, 200 University Avenue West, Waterloo, Ontario, Canada
E-mail: s5taylor@sciborg.uwaterloo.ca

Abstract

Activation of a model tripartate prodrug was achieved by abzyme-catalyzed hydrolysis of an N-methylcarbamate moiety followed by a spontaneous 1,6-elimination reaction.

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Article information

DOI
https://doi.org/10.1039/B103971G
Article type
Communication
Submitted
26 Apr 2001
Accepted
07 Jun 2001
First published
11 Jul 2001

Chem. Commun., 2001, 1386-1387

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Antibody-catalyzed activation of a model tripartate prodrug by a tandem hydrolysis–1,6-elimination reaction

A. N. Dinaut and S. D. Taylor, Chem. Commun., 2001, 1386 DOI: 10.1039/B103971G

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