Issue 20, 2001
From the journal:

Chemical Communications

Sequence fidelity of a template-directed PNA-ligation reactionPNA = peptide nucleic acid.12

Amos Mattesa  and  Oliver Seitz*a  

* Corresponding authors

a Max-Planck-Institut für Molekulare Physiologie, Otto-Hahn-Str. 11, Dortmund, Germany and Institut für Organische Chemie, Universität Dortmund, Germany
E-mail: oliver.seitz@mpi-dortmund.mpg.de
Fax: 0049 231 1332499
Tel: 0049 231 1332424

Abstract

The ligation method and an appended duplex-stabilizing dye affect both yield and sequence selectivity of a template-controlled PNA-ligation. The highest selectivity was obtained with a peptide condensation that formed an abasic site.

Graphical abstract: Sequence fidelity of a template-directed PNA-ligation reaction

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Article information

DOI
https://doi.org/10.1039/B106109G
Article type
Communication
Submitted
10 Jul 2001
Accepted
29 Aug 2001
First published
14 Sep 2001

Chem. Commun., 2001, 2050-2051

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Sequence fidelity of a template-directed PNA-ligation reaction

A. Mattes and O. Seitz, Chem. Commun., 2001, 2050 DOI: 10.1039/B106109G

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