Issue 20, 2001
From the journal:

Chemical Communications

Biosynthesis of the vancomycin group of antibiotics: characterisation of a type III polyketide synthase in the pathway to (S)-3,5-dihydroxyphenylglycineElectronic supplementary information (ESI) available: electrospray mass spectrum of DhpaS. See http://www.rsc.org/suppdata/cc/b1/b106638b/

Tsung-Lin Li,a   Oliver W. Choroba,a   Hui Hong,a   Dudley H. Williamsa  and  Jonathan B. Spencer*a  

* Corresponding authors

a Cambridge Centre for Molecular Recognition, Department of Chemistry, Cambridge University, Lensfield Road, Cambridge, UK
E-mail: jbs20@cam.ac.uk;
Fax: 44 1223 336362;
Tel: 44 1223 331696

Abstract

3,5-dihydroxyphenylacetate, a precursor for the non-proteinogenic amino acid 3,5-dihydroxyphenylglycine occurring in glycopeptide antibiotics, is determined to be catalysed by a type III polyketide synthase using malonyl-CoA as a starter unit.

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Article information

DOI
https://doi.org/10.1039/B106638B
Article type
Communication
Submitted
23 Jul 2001
Accepted
30 Aug 2001
First published
02 Oct 2001

Chem. Commun., 2001, 2156-2157

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Biosynthesis of the vancomycin group of antibiotics: characterisation of a type III polyketide synthase in the pathway to (S)-3,5-dihydroxyphenylglycine

T. Li, O. W. Choroba, H. Hong, D. H. Williams and J. B. Spencer, Chem. Commun., 2001, 2156 DOI: 10.1039/B106638B

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