Issue 19, 2001
From the journal:

Chemical Communications

Asymmetric synthesis of 2-azido-1-arylethanols from azido aryl ketone–β-cyclodextrin complexes and sodium borohydride in waterIICT Communication No. 4769.

M. Arjun Reddy,a   N. Bhanumathia  and  K. Rama Rao*a  

* Corresponding authors

a Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad-500 007, India
E-mail: ramaraok@iict.ap.nic.in

Abstract

β-Cyclodextrin catalyses for the first time the asymmetric reduction of α-azido aryl ketones to corresponding alcohols of great significance using sodium borohydride in water. The azido group appeared to be the best fit among various groups studied. This asymmetric reduction using water as solvent overcomes many of the drawbacks in the existing methodologies.

Graphical abstract: Asymmetric synthesis of 2-azido-1-arylethanols from azido aryl ketone–β-cyclodextrin complexes and sodium borohydride in water

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Article information

DOI
https://doi.org/10.1039/B106736M
Article type
Communication
Submitted
25 Jul 2001
Accepted
21 Aug 2001
First published
10 Sep 2001

Chem. Commun., 2001, 1974-1975

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Asymmetric synthesis of 2-azido-1-arylethanols from azido aryl ketone–β-cyclodextrin complexes and sodium borohydride in water

M. A. Reddy, N. Bhanumathi and K. R. Rao, Chem. Commun., 2001, 1974 DOI: 10.1039/B106736M

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