Issue 8, 2002
From the journal:

Chemical Communications

Castanospermine–trehazolin hybrids: a new family of glycomimetics with tuneable glycosidase inhibitory properties†

M. Isabel García-Moreno,a   Paula Díaz-Pérez,a   Carmen Ortiz Mellet*a  and  José M. García Fernández*b  

* Corresponding authors

a Departamento de Química Orgánica, Facultad de Química, Universidad de Sevilla, Apartado 553, Sevilla, Spain
E-mail: mellet@us.es
Fax: +34 954624960
Tel: +34 954557150

b Instituto de Investigaciones Químicas, CSIC, Américo Vespucio s/n, Isla de la Cartuja, Sevilla, Spain
E-mail: jogarcia@cica.es
Fax: +34 954460565
Tel: +34 954489559

Abstract

Bicyclic azasugar glycomimetics related to castanospermine and trehazolin have been prepared from sugar carbodiimides via aminooxazoline intermediates; preliminary enzyme inhibition tests showed a marked dependence of the selectivity and potency towards α and β-glucosidases upon the nature of the exocyclic substituent.

Graphical abstract: Castanospermine–trehazolin hybrids: a new family of glycomimetics with tuneable glycosidase inhibitory properties

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Article information

DOI
https://doi.org/10.1039/B200162D
Article type
Communication
Submitted
08 Jan 2002
Accepted
06 Mar 2002
First published
19 Mar 2002

Chem. Commun., 2002, 848-849

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Castanospermine–trehazolin hybrids: a new family of glycomimetics with tuneable glycosidase inhibitory properties

M. I. García-Moreno, P. Díaz-Pérez, C. O. Mellet and J. M. G. Fernández, Chem. Commun., 2002, 848 DOI: 10.1039/B200162D

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