Issue 6, 2002

Regioselective reduction of maleimide and citraconimide derivatives: general preparation of 5-hydroxy-1,5-dihydropyrrol-2-one

Abstract

NaBH4 reduction of citraconimide derivatives regioselectively afforded 5-hydroxy-4-methyl-1,5-dihydropyrrol-2-ones, whereas NaBH4–CeCl3 or DIBAL-H reduction gave 5-hydroxy-3-methyl-1,5-dihydropyrrol-2-ones.

Graphical abstract: Regioselective reduction of maleimide and citraconimide derivatives: general preparation of 5-hydroxy-1,5-dihydropyrrol-2-one

Article information

Article type
Communication
Submitted
21 Jan 2002
Accepted
04 Feb 2002
First published
12 Feb 2002

J. Chem. Soc., Perkin Trans. 1, 2002, 707-709

Regioselective reduction of maleimide and citraconimide derivatives: general preparation of 5-hydroxy-1,5-dihydropyrrol-2-one

N. Mase, T. Nishi, M. Hiyoshi, K. Ichihara, J. Bessho, H. Yoda and K. Takabe, J. Chem. Soc., Perkin Trans. 1, 2002, 707 DOI: 10.1039/B200729K

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