Issue 12, 2002

Synthesis of amino acid derivatives via enantio- and diastereoselective Pd-catalyzed allylic substitutions with a non-stabilized enolate as nucleophile

Abstract

Diastereomer ratios of up to 95∶5 and enantiomeric excesses of up to 95% were achieved in Pd-catalyzed asymmetric allylic substitutions with zinc enolates of glycine esters as nucleophiles; a remarkable effect of the ligand on the diastereoselectivity of the substitution was found.

Graphical abstract: Synthesis of amino acid derivatives via enantio- and diastereoselective Pd-catalyzed allylic substitutions with a non-stabilized enolate as nucleophile

Article information

Article type
Communication
Submitted
18 Apr 2002
Accepted
01 May 2002
First published
15 May 2002

Chem. Commun., 2002, 1270-1271

Synthesis of amino acid derivatives via enantio- and diastereoselective Pd-catalyzed allylic substitutions with a non-stabilized enolate as nucleophile

T. D. Weiß, G. Helmchen and U. Kazmaier, Chem. Commun., 2002, 1270 DOI: 10.1039/B203791M

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