Issue 20, 2002
From the journal:

Chemical Communications

Synthesis of α-amino acid derivatives and aminesviaactivation of simple alkyl halides by zinc in water

Taisheng Huang,a   Charlene C. K. Keha  and  Chao-Jun Li*a  

* Corresponding authors

a Department of Chemistry, Tulane University, New Orleans, LA, USA
E-mail: cjli@tulane.edu
Fax: 5048655596
Tel: 504-8655573

Abstract

A method for the synthesis of α-amino acid derivatives and amines is developed via a zinc-mediated conjugate addition reaction of alkyl halides to α-phthalimidoacrylate derivatives and nucleophilic addition to imines in the presence of NH4Cl in water. No reaction was observed in the absence of water.

Graphical abstract: Synthesis of α-amino acid derivatives and amines via activation of simple alkyl halides by zinc in water

About
Cited by
Related
Download options Please wait...

Article information

DOI
https://doi.org/10.1039/B204585K
Article type
Communication
Submitted
13 May 2002
Accepted
09 Jul 2002
First published
24 Sep 2002

Chem. Commun., 2002, 2440-2441

Permissions

Request permissions

Synthesis of α-amino acid derivatives and amines via activation of simple alkyl halides by zinc in water

T. Huang, C. C. K. Keh and C. Li, Chem. Commun., 2002, 2440 DOI: 10.1039/B204585K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements