Issue 17, 2002
From the journal:

Chemical Communications

Enantioselective synthesis and application of the highly fluorescent and environment-sensitive amino acid 6-(2-dimethylaminonaphthoyl) alanine (DANA)†

Mark Nitz,a   Adam R. Mezo,a   Mayssam H. Alia  and  Barbara Imperiali*a  

* Corresponding authors

a Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
E-mail: imper@mit.edu

Abstract

6-(2-Dimethylaminonaphthoyl) alanine (DANA) was prepared via an enantioselective synthesis and incorporated into the S-peptide of RNase S establishing the large changes in fluorescence that can occur upon peptide–protein interaction.

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Article information

DOI
https://doi.org/10.1039/B205224E
Article type
Communication
Submitted
30 May 2002
Accepted
04 Jul 2002
First published
29 Jul 2002

Chem. Commun., 2002, 1912-1913

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Enantioselective synthesis and application of the highly fluorescent and environment-sensitive amino acid 6-(2-dimethylaminonaphthoyl) alanine (DANA)

M. Nitz, A. R. Mezo, M. H. Ali and B. Imperiali, Chem. Commun., 2002, 1912 DOI: 10.1039/B205224E

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