Issue 20, 2002
From the journal:

Chemical Communications

Tyrosine 92 of aristolochene synthase directs cyclisation of farnesyl pyrophosphate†

Melanie J. Calvert,a   Susan E. Taylora  and  Rudolf K. Allemann*a  

* Corresponding authors

a School of Chemical Sciences, University of Birmingham, Edgbaston, Birmingham, UK
E-mail: r.k.allemann@bham.ac.uk
Fax: 44 121 414 4446
Tel: 44 121 414 4359

Abstract

A mutant of Aristolochene Synthase (AS), in which Tyr 92 was replaced by Val, produced the alicyclic β-(E)-farnesene as the major product, indicating that cyclisation of FPP is controlled by Tyr 92 in AS.

Graphical abstract: Tyrosine 92 of aristolochene synthase directs cyclisation of farnesyl pyrophosphate

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Article information

DOI
https://doi.org/10.1039/B206517G
Article type
Communication
Submitted
08 Jul 2002
Accepted
19 Aug 2002
First published
19 Sep 2002

Chem. Commun., 2002, 2384-2385

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Tyrosine 92 of aristolochene synthase directs cyclisation of farnesyl pyrophosphate

M. J. Calvert, S. E. Taylor and R. K. Allemann, Chem. Commun., 2002, 2384 DOI: 10.1039/B206517G

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