Issue 13, 2003

N-Methylpiperazinocarbonyl-2′,3′-BcNA and 4′-C-(N-methylpiperazino)methyl-DNA: introduction of basic functionalities facing the major groove and the minor groove of a DNA:DNA duplex

Abstract

Piperazino-functionalized 2′,3′-BcNA and 4′-C-hydroxymethyl-DNA are appropriate molecular architectures for the introduction of basic functionalities facing the major groove and the minor groove of nucleic acid duplexes, respectively. 4′-C-(N-Methylpiperazino)methyl-DNA monomers induce significantly increased thermal stability of a DNA:DNA duplex.

Graphical abstract: N-Methylpiperazinocarbonyl-2′,3′-BcNA and 4′-C-(N-methylpiperazino)methyl-DNA: introduction of basic functionalities facing the major groove and the minor groove of a DNA:DNA duplex

Article information

Article type
Communication
Submitted
14 Mar 2003
Accepted
06 May 2003
First published
04 Jun 2003

Chem. Commun., 2003, 1604-1605

N-Methylpiperazinocarbonyl-2′,3′-BcNA and 4′-C-(N-methylpiperazino)methyl-DNA: introduction of basic functionalities facing the major groove and the minor groove of a DNA:DNA duplex

M. Raunkjær, T. Bryld and J. Wengel, Chem. Commun., 2003, 1604 DOI: 10.1039/B302963H

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