Issue 13, 2003
From the journal:

Organic & Biomolecular Chemistry

Synthesis and structural study of two new heparin-like hexasaccharides

Ricardo Lucas,a   Jesús Angulo,a   Pedro M. Nietoa  and  Manuel Martín-Lomas*a  

* Corresponding authors

a Grupo de Carbohidratos, Instituto de Investigaciones Químicas, CSIC, Américo Vespucio s/n, Isla de la Cartuja, 41092 Sevilla, Spain

Abstract

Two new heparin-like hexasaccharides, 5 and 6, have been synthesised using a convergent block strategy and their solution conformations have been determined by NMR spectroscopy and molecular modelling. Both hexasaccharides contain the basic structural motif of the regular region of heparin but with negative charge distributions which have been designed to get insight into the mechanism of fibroblast growth factors (FGFs) activation.

Graphical abstract: Synthesis and structural study of two new heparin-like hexasaccharides

About
Cited by
Related
Download options Please wait...

Article information

DOI
https://doi.org/10.1039/B303115B
Article type
Paper
Submitted
20 Mar 2003
Accepted
20 May 2003
First published
02 Jun 2003

Org. Biomol. Chem., 2003,1, 2253-2266

Permissions

Request permissions

Synthesis and structural study of two new heparin-like hexasaccharides

R. Lucas, J. Angulo, P. M. Nieto and M. Martín-Lomas, Org. Biomol. Chem., 2003, 1, 2253 DOI: 10.1039/B303115B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements