Regioselective hydroxylation of the xylyl linker in a diiron(III) complex having a carboxylate-rich ligand with H2O2

Hideki Furutachi; Mizue Murayama; Amane Shiohara; Satoshi Yamazaki; Shuhei Fujinami; Akira Uehara; Masatatsu Suzuki; Seiji Ogo; Yoshihito Watanabe; Yonezo Maeda

doi:10.1039/B304171A

Regioselective hydroxylation of the xylyl linker in a diiron(iii) complex having a carboxylate-rich ligand with H₂O₂†

Hideki Furutachi,^a Mizue Murayama,^a Amane Shiohara,^a Satoshi Yamazaki,^a Shuhei Fujinami,^a Akira Uehara,^a Masatatsu Suzuki,*^a Seiji Ogo,^b Yoshihito Watanabe^c and Yonezo Maeda^d

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^a Department of Chemistry, Faculty of Science, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan
E-mail: suzuki@cacheibm.s.kanazawa-u.ac.jp

^b Department of Material and Life Science, Graduate School of Engineering, Osaka University, Suita, Osaka 565-0871, Japan

^c Department of Chemistry, Graduate School of Science, Nagoya University, Chikusa-ku, Nagoya 464-8602, Japan

^d Department of Chemistry, Faculty of Science, Kyushu University, Hakozaki, Fukuoka 812-0053, Japan

Abstract

Reaction of a diiron(III) complex having a xylta⁴⁻ ligand (N,N,N′,N′-m-xylylenediamine tetraacetate) with H₂O₂ resulted in regioselective hydroxylation of the m-xylyl linker. The reaction mimics the self-hydroxylation of a phenylalanine side chain found for ribonucleotide reductase (R2-W48F/D84E).

Chemical Communications

Regioselective hydroxylation of the xylyl linker in a diiron(iii) complex having a carboxylate-rich ligand with H₂O₂†

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Regioselective hydroxylation of the xylyl linker in a diiron(III) complex having a carboxylate-rich ligand with H₂O₂

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