Issue 17, 2003
From the journal:

Chemical Communications

Stabilisation of eudesmane cation by tryptophan 334 during aristolochene synthase catalysis†

Athina Deligeorgopoulou,a   Susan E. Taylor,a   Silvia Forcata  and  Rudolf K. Allemann*a  

* Corresponding authors

a School of Chemical Sciences, University of Birmingham, Edbaston, Birmingham, UK
E-mail: r.k.allemann@bham.ac.uk
Fax: 44 121-414 4446
Tel: 44 121 414 4359

Abstract

Analysis of the hydrocarbons produced during catalysis by mutants of aristolochene synthase from Penicillium roqueforti indicated that Trp 334 had a pivotal function for the efficient production of aristolochene from farnesylpyrophosphate most likely by stabilising the intermediate, eudesmane cation.

Graphical abstract: Stabilisation of eudesmane cation by tryptophan 334 during aristolochene synthase catalysis

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Article information

DOI
https://doi.org/10.1039/B306867F
Article type
Communication
Submitted
17 Jun 2003
Accepted
09 Jul 2003
First published
22 Jul 2003

Chem. Commun., 2003, 2162-2163

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Stabilisation of eudesmane cation by tryptophan 334 during aristolochene synthase catalysis

A. Deligeorgopoulou, S. E. Taylor, S. Forcat and R. K. Allemann, Chem. Commun., 2003, 2162 DOI: 10.1039/B306867F

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