Issue 18, 2003
From the journal:

Chemical Communications

Efficient, intermolecular, oxidative radical alkylation of heteroaromatic systems under “tin-free” conditions

Yazmin M. Osornio,a   Raymundo Cruz-Almanza,a   Vicente Jiménez-Montañoa  and  Luis D. Miranda*a  

* Corresponding authors

a Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior S. N., Ciudad Universitaria, Coyoacán, México, D. F. 04510, México
E-mail: mirandald@correo.unam.mx
Fax: (+52) 55 56 16 22 17
Tel: (+52) 55 56 22 44 40

Abstract

Novel and efficient radical alkylation of several heterocyclic systems including pyrroles, indoles, furan and thiophenes is described using xanthate based radical chemistry. The present methodology could be used to provide rapid access to various nonsteroidal antiinflammatory drugs.

Graphical abstract: Efficient, intermolecular, oxidative radical alkylation of heteroaromatic systems under “tin-free” conditions

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Article information

DOI
https://doi.org/10.1039/B306966D
Article type
Communication
Submitted
18 Jun 2003
Accepted
21 Jul 2003
First published
01 Aug 2003

Chem. Commun., 2003, 2316-2317

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Efficient, intermolecular, oxidative radical alkylation of heteroaromatic systems under “tin-free” conditions

Y. M. Osornio, R. Cruz-Almanza, V. Jiménez-Montaño and L. D. Miranda, Chem. Commun., 2003, 2316 DOI: 10.1039/B306966D

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