Issue 17, 2003

Synthesis and properties of a novel bridged nucleic acid with a P3′ → N5′ phosphoramidate linkage, 5′-amino-2′,4′-BNA

Abstract

5′-Amino-2′,4′-BNA, a novel analogue of BNA series compounds, was successfully synthesized, and its incorporated oligonucleotides showed potent duplex- and triplex-forming ability and resistance against snake venom phosphodiesterase.

Graphical abstract: Synthesis and properties of a novel bridged nucleic acid with a P3′ → N5′ phosphoramidate linkage, 5′-amino-2′,4′-BNA

Supplementary files

Article information

Article type
Communication
Submitted
25 Jun 2003
Accepted
11 Jul 2003
First published
25 Jul 2003

Chem. Commun., 2003, 2202-2203

Synthesis and properties of a novel bridged nucleic acid with a P3′ → N5′ phosphoramidate linkage, 5′-amino-2′,4′-BNA

S. Obika, O. Nakagawa, A. Hiroto, Y. Hari and T. Imanishi, Chem. Commun., 2003, 2202 DOI: 10.1039/B307290H

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