Issue 20, 2003
From the journal:

Chemical Communications

Stereoinversion of β- and γ-substituted α-amino acids using a chemo-enzymatic oxidation–reduction procedure

Alexis Enright,a   Francois-Rene Alexandre,a   Geoffrey Roff,a   Ian G. Fotheringham,a   Michael J. Dawsonb  and  Nicholas J. Turner*a  

* Corresponding authors

a School of Chemistry, The University of Edinburgh, King's Buildings, West Mains Road, Edinburgh, UK
E-mail: n.j.turner@ed.ac.uk

b GlaxoSmithKline R&D, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, UK

Abstract

Both D- and L-β- and γ-substituted α-amino acids can be interconverted to their respective L- and D- diastereoisomers by treatment with an enantioselective amino acid oxidase and a chemical reducing agent.

Graphical abstract: Stereoinversion of β- and γ-substituted α-amino acids using a chemo-enzymatic oxidation–reduction procedure

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Article information

DOI
https://doi.org/10.1039/B309787K
Article type
Communication
Submitted
14 Aug 2003
Accepted
08 Sep 2003
First published
23 Sep 2003

Chem. Commun., 2003, 2636-2637

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Stereoinversion of β- and γ-substituted α-amino acids using a chemo-enzymatic oxidation–reduction procedure

A. Enright, F. Alexandre, G. Roff, I. G. Fotheringham, M. J. Dawson and N. J. Turner, Chem. Commun., 2003, 2636 DOI: 10.1039/B309787K

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