The regiospecific Fischer indole reaction in choline chloride·2ZnCl2 with product isolation by direct sublimation from the ionic liquid

Raul Calderon Morales; Vasuki Tambyrajah; Paul R. Jenkins; David L. Davies; Andrew P. Abbott

doi:10.1039/B313655H

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The regiospecific Fischer indole reaction in choline chloride·2ZnCl₂ with product isolation by direct sublimation from the ionic liquid†

Raul Calderon Morales,^a Vasuki Tambyrajah,^a Paul R. Jenkins,*^a David L. Davies^a and Andrew P. Abbott^a

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^a The Green Chemistry Research Group, Department of Chemistry, University of Leicester, Leicester, UK

Abstract

The Fischer indole synthesis occurs in high yield with one equivalent of the ionic liquid choline chloride·2ZnCl₂; exclusive formation of 2,3-disubstituted indoles is observed in the reaction of alkyl methyl ketones, and the products readily sublime directly from the ionic liquid.

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Experimental details DOC (561K)

Article information

DOI: https://doi.org/10.1039/B313655H
Article type: Communication
Submitted: 26 Oct 2003
Accepted: 21 Nov 2003
First published: 12 Dec 2003

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Chem. Commun., 2004, 158-159

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The regiospecific Fischer indole reaction in choline chloride·2ZnCl₂ with product isolation by direct sublimation from the ionic liquid

R. Calderon Morales, V. Tambyrajah, P. R. Jenkins, D. L. Davies and A. P. Abbott, Chem. Commun., 2004, 158 DOI: 10.1039/B313655H

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