Issue 3, 2004
From the journal:

Green Chemistry

Ionic liquid promoted novel and efficient one pot synthesis of 3,4-dihydropyrimidin-2-(1H)-ones at ambient temperature under ultrasound irradiation

Atul R. Gholap,a   K. Venkatesan,a   Thomas Daniel,a   R. J. Lahotia  and  K. V. Srinivasan*a  

* Corresponding authors

a Organic Chemistry; Technology Division, National Chemical Laboratory, Dr. Homi Bhabha Road, Pune-411 008, Maharashtra, India
E-mail: kvsri@dalton.ncl.res.in
Fax: +91-20-5893614

Abstract

3,4-Dihydropyrimidin-2-(1H)-ones have been synthesized in excellent yields in short reaction time at ambient temperature in the absence of any added catalyst by the reaction of aromatic or aliphatic aldehydes with ethyl acetoacetate (EAA) and urea (or thiourea) in room temperature ionic liquid (IL) under ultrasound irradiation. The evidence for the role of IL in promoting this multicomponent reaction has been given. Based on this evidence, a plausible mechanistic pathway has been postulated.

Graphical abstract: Ionic liquid promoted novel and efficient one pot synthesis of 3,4-dihydropyrimidin-2-(1H)-ones at ambient temperature under ultrasound irradiation

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Article information

DOI
https://doi.org/10.1039/B314015F
Article type
Paper
Submitted
04 Nov 2003
Accepted
23 Dec 2003
First published
20 Jan 2004

Green Chem., 2004,6, 147-150

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Ionic liquid promoted novel and efficient one pot synthesis of 3,4-dihydropyrimidin-2-(1H)-ones at ambient temperature under ultrasound irradiation

A. R. Gholap, K. Venkatesan, T. Daniel, R. J. Lahoti and K. V. Srinivasan, Green Chem., 2004, 6, 147 DOI: 10.1039/B314015F

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