Issue 3, 2004

Ethyl glucoside in human urine following dietary exposure: detection by 1H NMR spectroscopy as a result of metabonomic screening of humans

Abstract

Metabonomic screening of human urine samples using 1H NMR spectroscopy has revealed the presence of signals resulting from the excretion of ethyl glucoside. Experiments in volunteers have demonstrated that this ethyl glucoside results from dietary exposure to the compound, which is present in beverages such as rice wine and sake, rather than representing a new route for the metabolism of ethanol by humans. The limited studies undertaken in volunteers indicate that ethyl glucoside has a longer biological half life than ethanol itself. The potential problems associated with using this glucoside metabolite as a marker of ethanol consumption are considered.

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Article information

Article type
Paper
Submitted
07 Nov 2003
Accepted
14 Jan 2004
First published
27 Jan 2004

Analyst, 2004,129, 259-264

Ethyl glucoside in human urine following dietary exposure: detection by 1H NMR spectroscopy as a result of metabonomic screening of humans

C. Teague, E. Holmes, E. Maibaum, J. Nicholson, H. Tang, Q. Chan, P. Elliott and I. Wilson, Analyst, 2004, 129, 259 DOI: 10.1039/B314316N

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