Loss of co-linearity by modular polyketide synthases: a mechanism for the evolution of chemical diversity

Abstract

Covering: the literature up to April 2004

Modular polyketide synthases biosynthesise natural products through successive Claisen-type condensations, where one module is responsible for one round of chain extension. This review describes recent findings where this rule of co-linearity is broken, either by one module being bypassed (skipping) or through one module being used for multiple chain extension events (stuttering).