Issue 11, 2004
From the journal:

Organic & Biomolecular Chemistry

PEG-supported synthesis of pyrazole oligoamides with peptide β-sheet affinity†

Kateřina Černovská,a   Miriam Kemter,a   Hans-Christoph Gallmeier,a   Petra Rzepecki,b   Thomas Schrader*b  and  Burkhard König*a  

* Corresponding authors

a Institut für Organische Chemie, Universität Regensburg, D-93040 Regensburg, Germany
E-mail: Burkhard.Koenig@chemie.uni-regensburg.de

b Fachbereich Chemie, Universität Marburg, D-35032 Marburg, Germany
E-mail: schradet@staff.uni-marburg.de

Abstract

Pyrazole amino acid oligoamides were prepared on polyethylene glycol starting from nitro pyrazole carboxylic acids or protected pyrazole amino acids. The polymer support facilitates product isolation during synthesis and makes the target oligoamides soluble in chloroform and water. This allows the determination of their binding properties towards peptides. Moderate affinity, which increases with the number of pyrazole units, is observed in chloroform and water.

Graphical abstract: PEG-supported synthesis of pyrazole oligoamides with peptide β-sheet affinity

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Article information

DOI
https://doi.org/10.1039/B401968G
Article type
Paper
Submitted
09 Feb 2004
Accepted
13 Apr 2004
First published
11 May 2004

Org. Biomol. Chem., 2004,2, 1603-1611

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PEG-supported synthesis of pyrazole oligoamides with peptide β-sheet affinity

K. Černovská, M. Kemter, H. Gallmeier, P. Rzepecki, T. Schrader and B. König, Org. Biomol. Chem., 2004, 2, 1603 DOI: 10.1039/B401968G

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