Issue 4, 2005
From the journal:

Chemical Communications

Selective attachment and release of a chemotherapeutic agent from the interior of a protein cage architecture†

Michelle L. Flenniken,ad   Lars O. Liepold,bd   Bridgid E. Crowley,bd   Deborah A. Willits,cd   Mark J. Youngcd  and  Trevor Douglasbd  

a Department of Microbiology, Montana State University, Lewis Hall, Bozeman MT, USA

b Department of Chemistry and Biochemistry, Montana State University, Gaines Hall, Bozeman MT, USA

c Department of Plant Sciences, Montana State University, ABS Facility, Bozeman MT, USA

d Center for Bio-Inspired Nanomaterials, Montana State University, Gaines Hall, Bozeman MT, USA
E-mail: tdouglas@chemistry.montana.edu
Fax: 406-994-5407
Tel: 406-994-6566

Abstract

The antitumor agent doxorubicin was covalently bound and selectively released in a pH dependent manner from the interior surface of a genetically modified small heat shock protein (Hsp) cage.

Graphical abstract: Selective attachment and release of a chemotherapeutic agent from the interior of a protein cage architecture

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Article information

DOI
https://doi.org/10.1039/B413435D
Article type
Communication
Submitted
02 Aug 2004
Accepted
12 Oct 2004
First published
02 Dec 2004

Chem. Commun., 2005, 447-449

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Selective attachment and release of a chemotherapeutic agent from the interior of a protein cage architecture

M. L. Flenniken, L. O. Liepold, B. E. Crowley, D. A. Willits, M. J. Young and T. Douglas, Chem. Commun., 2005, 447 DOI: 10.1039/B413435D

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