Issue 2, 2005

New C–N and C–C bond forming reactions catalyzed by titanium complexes

Abstract

Titanium(IV) complexes with two basic dimethylamido ligands can be efficient catalysts for alkyne hydroamination by primary amines. Readily prepared pyrrolyl ligands have proven to be especially useful in generating active catalysts for hydroamination and hydrohydrazination. From these reactions, new methodologies for the synthesis of imines, hydrazones, α,β-unsaturated imines, pyridines, indoles, and pyrroles have developed. In addition, a new reaction that is mechanistically related to hydroamination, alkyne iminoamination, has been discovered. Iminoamination, which is a multicomponent coupling between an amine, alkyne, and isonitrile, provides unsymmetrical α,β-unsaturated β-iminoamines in a single, titanium-catalyzed step.

Article information

Article type
Perspective
Submitted
11 Oct 2004
Accepted
19 Nov 2004
First published
13 Dec 2004

Dalton Trans., 2005, 225-233

New C–N and C–C bond forming reactions catalyzed by titanium complexes

A. L. Odom, Dalton Trans., 2005, 225 DOI: 10.1039/B415701J

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