A glucosamine–dipicolylamine conjugate of 99mTc(I) and 186Re(I) for use in imaging and therapy

Tim Storr; Cara L. Fisher; Yuji Mikata; Shigenobu Yano; Michael J. Adam; Chris Orvig

doi:10.1039/B416040A

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A glucosamine–dipicolylamine conjugate of ^99mTc(i) and ¹⁸⁶Re(i) for use in imaging and therapy†

Tim Storr,^a Cara L. Fisher,^ab Yuji Mikata,^c Shigenobu Yano,^d Michael J. Adam*^b and Chris Orvig*^a

Author affiliations

* Corresponding authors

^a Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, British Columbia, Canada
E-mail: orvig@chem.ubc.ca
Fax: 1 604 822 2847
Tel: 1 604 822 4449

^b TRIUMF, 4004 Wesbrook Mall, Vancouver, British Columbia, Canada
E-mail: adam@triumf.ca
Fax: 1 604 222 1074
Tel: 1 604 222 7527

^c KYOUSEI Science Center, Nara Women's University, Nara, Japan

^d Division of Material Science, Nara Women's University, Nara, Japan

Abstract

The synthesis and metal complexation of a glucosamine-appended 2,2′-dipicolylamine ligand to the tricarbonyls of ^99mTc and ¹⁸⁶Re is described; the ligand was found to bind in a tridentate fashion with the glucosamine function remaining pendant, and the ^99mTc complex was found to exhibit exceptional stability towards in vitro ligand exchange experiments.

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Supplementary files

Synthesis and characterisation of L 1 and characterisation data of [Re( L 1)(CO) ₃]Br PDF (28K)

Article information

DOI: https://doi.org/10.1039/B416040A
Article type: Communication
Submitted: 18 Oct 2004
Accepted: 12 Jan 2005
First published: 21 Jan 2005

Download Citation

Dalton Trans., 2005, 654-655

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A glucosamine–dipicolylamine conjugate of ^99mTc(I) and ¹⁸⁶Re(I) for use in imaging and therapy

T. Storr, C. L. Fisher, Y. Mikata, S. Yano, M. J. Adam and C. Orvig, Dalton Trans., 2005, 654 DOI: 10.1039/B416040A

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Dalton Transactions